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Structure paper

TitlePrevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase.
Journal, issue, pagesNat Commun, Vol. 13, Page 6443-6443, Year 2022
Publish dateFeb 28, 2022 (structure data deposition date)
AuthorsLei, R. / Tan, T.J.C. / Hernandez Garcia, A. / Wang, Y. / Diefenbacher, M. / Teo, C. / Gopan, G. / Tavakoli Dargani, Z. / Teo, Q.W. / Graham, C.S. ...Lei, R. / Tan, T.J.C. / Hernandez Garcia, A. / Wang, Y. / Diefenbacher, M. / Teo, C. / Gopan, G. / Tavakoli Dargani, Z. / Teo, Q.W. / Graham, C.S. / Brooke, C.B. / Nair, S.K. / Wu, N.C.
External linksNat Commun / PubMed:36307418
MethodsX-ray diffraction
Resolution1.4 - 1.65 Å
Structure data

PDB-7u4e:
Neuraminidase from influenza virus A/Bilthoven/17938/1969(H3N2)
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-7u4f:
Neuraminidase from influenza virus A/Moscow/10/1999(H3N2)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-7u4g:
Neuraminidase from influenza virus A/Shandong/9/1993(H3N2)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ZMR:
ZANAMIVIR / medication, inhibitor*YM

Source
  • influenza a virus (a/bilthoven/17938/1969(h3n2))
  • influenza a virus (a/moscow/10/1999(h3n2))
  • influenza a virus (a/shandong/9/1993(h3n2))
KeywordsVIRAL PROTEIN / Hydrolase / neuraminidase / influenza

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