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-Structure paper
Title | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 13551-13571, Year 2021 |
Publish date | Jul 7, 2021 (structure data deposition date) |
Authors | Liu, L. / Tang, M. / Pragani, R. / Whitby, F.G. / Zhang, Y.Q. / Balakrishnan, B. / Fang, Y. / Karavadhi, S. / Tao, D. / LeClair, C.A. ...Liu, L. / Tang, M. / Pragani, R. / Whitby, F.G. / Zhang, Y.Q. / Balakrishnan, B. / Fang, Y. / Karavadhi, S. / Tao, D. / LeClair, C.A. / Hall, M.D. / Marugan, J.J. / Boxer, M. / Shen, M. / Hill, C.P. / Lai, K. / Patnaik, S. |
External links | J. Med. Chem. / PubMed:34491744 |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.4 Å |
Structure data | PDB-7rcl: PDB-7rcm: PDB-7s49: PDB-7s4c: |
Chemicals | ChemComp-GLA: ChemComp-ADP: ChemComp-PO4: ChemComp-MG: ChemComp-NA: ChemComp-HOH: ChemComp-GOL: ChemComp-4QI: ChemComp-V3V: |
Source |
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Keywords | SUGAR BINDING PROTEIN / GALK / galactokinase / Galactose / ADP / disulfide / Transferase/Inhibitor / Inhibitor / Transferase-Inhibitor complex |