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TitleA novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Journal, issue, pagesPlos Pathog., Vol. 18, Page e1010409-e1010409, Year 2022
Publish dateAug 23, 2021 (structure data deposition date)
AuthorsBeutler, N. / Pholcharee, T. / Oyen, D. / Flores-Garcia, Y. / MacGill, R.S. / Garcia, E. / Calla, J. / Parren, M. / Yang, L. / Volkmuth, W. ...Beutler, N. / Pholcharee, T. / Oyen, D. / Flores-Garcia, Y. / MacGill, R.S. / Garcia, E. / Calla, J. / Parren, M. / Yang, L. / Volkmuth, W. / Locke, E. / Regules, J.A. / Dutta, S. / Emerling, D. / Early, A.M. / Neafsey, D.E. / Winzeler, E. / King, C.R. / Zavala, F. / Burton, D.R. / Wilson, I.A. / Rogers, T.F.
External linksPlos Pathog. / PubMed:35344575
MethodsX-ray diffraction
Resolution1.761 - 2.8 Å
Structure data

PDB-7rxi:
Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7rxj:
Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 2.345 Å

PDB-7rxl:
Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 1.823 Å

PDB-7rxp:
Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 1.761 Å

PDB-7s0x:
Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • plasmodium falciparum (isolate 3d7) (eukaryote)
KeywordsIMMUNE SYSTEM / Malaria / Antibody / Sporozoite / Circumsporozoite protein / alpha-TSR domain

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