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TitleAntitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- d ]pyrimidine RET Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 12, Page 1912-1919, Year 2021
Publish dateAug 17, 2021 (structure data deposition date)
AuthorsMathison, C.J.N. / Yang, Y. / Nelson, J. / Huang, Z. / Jiang, J. / Chianelli, D. / Rucker, P.V. / Roland, J. / Xie, Y.F. / Epple, R. ...Mathison, C.J.N. / Yang, Y. / Nelson, J. / Huang, Z. / Jiang, J. / Chianelli, D. / Rucker, P.V. / Roland, J. / Xie, Y.F. / Epple, R. / Bursulaya, B. / Lee, C. / Gao, M.Y. / Shaffer, J. / Briones, S. / Sarkisova, Y. / Galkin, A. / Li, L. / Li, N. / Li, C. / Hua, S. / Kasibhatla, S. / Kinyamu-Akunda, J. / Kikkawa, R. / Molteni, V. / Tellew, J.E.
External linksAcs Med. Chem. Lett. / PubMed:34917254
MethodsX-ray diffraction
Resolution3.51 Å
Structure data

PDB-7run:
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 3.51 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-7QU:
1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / tyrosine-protein kinase / inhibitor / cell adhesion / TRANSFERASE-TRANSFERASE INHIBITOR complex

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