タイトル | RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 119, Year 2022 |
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掲載日 | 2021年7月20日 (構造データの登録日) |
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著者 | Oh, J. / Jia, T. / Xu, J. / Chong, J. / Dervan, P.B. / Wang, D. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:35022237 |
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手法 | X線回折 |
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解像度 | 1.8 - 3.7 Å |
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構造データ | PDB-7ril: Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7rim: RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-7rip: RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 soaked with CTP 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-7riq: RNA polymerase II elongation complex scaffold 1 without polyamide 手法: X-RAY DIFFRACTION / 解像度: 3.0 Å PDB-7riw: RNA polymerase II elongation complex scaffold 2, without polyamide 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-7rix: RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å PDB-7riy: RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 soaked with UTP 手法: X-RAY DIFFRACTION / 解像度: 3.7 Å |
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化合物 | ChemComp-5N0: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid
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由来 | - synthetic construct (人工物)
- saccharomyces cerevisiae (strain atcc 204508 / s288c) (パン酵母)
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キーワード | DNA (デオキシリボ核酸) / Polyamide (ポリアミド) / small molecule (小分子) / DNA binding molecule / anticancer agent / DNA BINDING PROTEIN/DNA/RNA / RNA polymerase II (RNAポリメラーゼII) / elongation complex / TRANSCRIPTION (転写 (生物学)) / DNA BINDING PROTEIN-DNA-RNA complex / unnatural base / TPT3 / NAM |
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