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TitleStructural basis of HIV-1 maturation inhibitor binding and activity.
Journal, issue, pagesNat Commun, Vol. 14, Page 1237-1237, Year 2023
Publish dateJun 25, 2021 (structure data deposition date)
AuthorsSarkar, S. / Zadrozny, K.K. / Zadorozhnyi, R. / Russell, R.W. / Quinn, C.M. / Kleinpeter, A. / Ablan, S. / Meshkin, H. / Perilla, J.R. / Freed, E.O. ...Sarkar, S. / Zadrozny, K.K. / Zadorozhnyi, R. / Russell, R.W. / Quinn, C.M. / Kleinpeter, A. / Ablan, S. / Meshkin, H. / Perilla, J.R. / Freed, E.O. / Ganser-Pornillos, B.K. / Pornillos, O. / Gronenborn, A.M. / Polenova, T.
External linksNat Commun / PubMed:36871077
MethodsNMR (solid-state)
Structure data

PDB-7r7p:
Immature HIV-1 CACTD-SP1 lattice with Bevirimat (BVM) and Inositol hexakisphosphate (IP6)
Method: SOLID-STATE NMR

PDB-7r7q:
Immature HIV-1 CACTD-SP1 lattice with Inositol hexakisphosphate (IP6)
Method: SOLID-STATE NMR

Chemicals

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

ChemComp-2I4:
3alpha-[(3-carboxy-3-methylbutanoyl)oxy]-8alpha,9beta,10alpha,13alpha,17alpha,19beta-lup-20(29)-en-28-oic acid

Source
  • human immunodeficiency virus 1
KeywordsPROTEIN BINDING / HIV-1 capsid / maturation inhibitors / HIV-AIDS

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