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TitleStructure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex.
Journal, issue, pagesSci Adv, Vol. 8, Issue 35, Page eabo7761, Year 2022
Publish dateSep 2, 2022
AuthorsJulien Bous / Aurélien Fouillen / Hélène Orcel / Stefano Trapani / Xiaojing Cong / Simon Fontanel / Julie Saint-Paul / Joséphine Lai-Kee-Him / Serge Urbach / Nathalie Sibille / Rémy Sounier / Sébastien Granier / Bernard Mouillac / Patrick Bron /
PubMed AbstractArrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling pathways. Recent structural studies shed light on the molecular mechanisms ...Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling pathways. Recent structural studies shed light on the molecular mechanisms involved in GPCR-arrestin coupling, but whether this process is conserved among GPCRs is poorly understood. Here, we report the cryo-electron microscopy active structure of the wild-type arginine-vasopressin V2 receptor (V2R) in complex with β-arrestin1. It reveals an atypical position of β-arrestin1 compared to previously described GPCR-arrestin assemblies, associated with an original V2R/β-arrestin1 interface involving all receptor intracellular loops. Phosphorylated sites of the V2R carboxyl terminus are clearly identified and interact extensively with the β-arrestin1 N-lobe, in agreement with structural data obtained with chimeric or synthetic systems. Overall, these findings highlight a notable structural variability among GPCR-arrestin signaling complexes.
External linksSci Adv / PubMed:36054364 / PubMed Central
MethodsEM (single particle)
Resolution4.23 - 4.73 Å
Structure data

14221

7r0c

EMDB-14221, PDB-7r0c:
Structure of the AVP-V2R-arrestin2-ScFv30 complex
Method: EM (single particle) / Resolution: 4.73 Å

14223

7r0j

EMDB-14223, PDB-7r0j:
Structure of the V2 receptor Cter-arrestin2-ScFv30 complex
Method: EM (single particle) / Resolution: 4.23 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / G-protein coupled receptor V2 receptor Arrestin 2 Vasopressin

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