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| Title | Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 64, Page 14603-14619, Year 2021 |
| Publish date | Jun 16, 2021 (structure data deposition date) |
 Authors | DeSelm, L. / Huck, B. / Lan, R. / Neagu, C. / Potnick, J. / Xiao, Y. / Chen, X. / Jones, R. / Richardson, T.E. / Heasley, B.H. ...DeSelm, L. / Huck, B. / Lan, R. / Neagu, C. / Potnick, J. / Xiao, Y. / Chen, X. / Jones, R. / Richardson, T.E. / Heasley, B.H. / Haxell, T. / Moore, J. / Tian, H. / Georgi, K. / Rohdich, F. / Sutton, A. / Johnson, T. / Mochalkin, I. / Jackson, J. / Lin, J. / Crowley, L. / Machl, A. / Clark, A. / Wilker, E. / Sherer, B. / Goutopoulos, A. |
 External links | J. Med. Chem. / PubMed:34596404 |
| Methods | X-ray diffraction |
| Resolution | 2.74 - 3 Å |
| Structure data |  PDB-7n91:  PDB-7n93: |
| Chemicals |  ChemComp-1RJ:  ChemComp-1SK:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/INHIBITOR / Kinase Domain / Inhibitor / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)