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Structure paper

TitleEXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
Journal, issue, pagesMol. Cell, Vol. 81, Page 2989-, Year 2021
Publish dateFeb 27, 2021 (structure data deposition date)
AuthorsHambarde, S. / Tsai, C.L. / Pandita, R.K. / Bacolla, A. / Maitra, A. / Charaka, V. / Hunt, C.R. / Kumar, R. / Limbo, O. / Le Meur, R. ...Hambarde, S. / Tsai, C.L. / Pandita, R.K. / Bacolla, A. / Maitra, A. / Charaka, V. / Hunt, C.R. / Kumar, R. / Limbo, O. / Le Meur, R. / Chazin, W.J. / Tsutakawa, S.E. / Russell, P. / Schlacher, K. / Pandita, T.K. / Tainer, J.A.
External linksMol. Cell / PubMed:34197737
MethodsX-ray diffraction
Resolution2.5 - 2.88 Å
Structure data

PDB-7lw7:
Human Exonuclease 5 crystal structure
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7lw8:
Human Exonuclease 5 crystal structure in complex with a ssDNA
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

PDB-7lw9:
Human Exonuclease 5 crystal structure in complex with ssDNA, Sm, and Na
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

PDB-7lwa:
Human Exonuclease 5 crystal structure (T88E) in complex with ssDNA and Mg
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-IMD:
IMIDAZOLE

ChemComp-ACT:
ACETATE ION

ChemComp-SM:
SAMARIUM (III) ION

ChemComp-NA:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / HYDROLASE/DNA / HYDROLASE-DNA complex

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