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Structure paper

TitleThe Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil.
Journal, issue, pagesBiochemistry, Vol. 60, Page 1120-1132, Year 2021
Publish dateJan 30, 2021 (structure data deposition date)
AuthorsForouzesh, D.C. / Beaupre, B.A. / Butrin, A. / Wawrzak, Z. / Liu, D. / Moran, G.R.
External linksBiochemistry / PubMed:33755421
MethodsX-ray diffraction
Resolution1.87 - 2 Å
Structure data

PDB-7ljs:
Porcine Dihydropyrimidine dehydrogenase (DPD) complexed with 5-Ethynyluracil (5EU) - Open Form
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7ljt:
Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked with 5-Ethynyluracil (5EU), NADPH - 20 minutes
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-7lju:
Porcine Dihydropyrimidine Dehydrogenase (DPD) crosslinked with 5-Ethynyluracil (5EU)
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-Y3G:
5-ethynylpyrimidine-2,4(1H,3H)-dione

ChemComp-HOH:
WATER

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-FNR:
1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL

Source
  • sus scrofa (pig)
KeywordsFLAVOPROTEIN / Dihydropyrimidine dehydrogenase / DPD / dehydrogenase / 5-Ethynyluracil / 5EU / inhibitor / inactivator / crosslinking

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