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-Structure paper
Title | Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 8287-8302, Year 2021 |
Publish date | Sep 26, 2020 (structure data deposition date) |
Authors | Blum, E. / Zhang, J. / Zaluski, J. / Einstein, D.E. / Korshin, E.E. / Kubas, A. / Gruzman, A. / Tochtrop, G.P. / Kiser, P.D. / Palczewski, K. |
External links | J. Med. Chem. / PubMed:34081480 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.15 Å |
Structure data | PDB-7k88: PDB-7k89: PDB-7k8g: PDB-7l0e: |
Chemicals | ChemComp-FE2: ChemComp-32M: ChemComp-PG4: ChemComp-NA: ChemComp-HOH: ChemComp-PLM: ChemComp-W4J: ChemComp-W9A: ChemComp-XQ7: ChemComp-PO4: |
Source |
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Keywords | ISOMERASE / HYDROLASE/INHIBITOR / Non-heme iron / isomerohydrolase / C8E6 / inhibitor / beta-propeller / HYDROLASE-INHIBITOR complex / beta propeller / monotopic membrane protein / HYDROLASE |