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-Structure paper
| Title | Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem., Vol. 52, Page 116500-116500, Year 2021 |
| Publish date | Jul 8, 2021 (structure data deposition date) |
Authors | Kori, S. / Shibahashi, Y. / Ekimoto, T. / Nishiyama, A. / Yoshimi, S. / Yamaguchi, K. / Nagatoishi, S. / Ohta, M. / Tsumoto, K. / Nakanishi, M. ...Kori, S. / Shibahashi, Y. / Ekimoto, T. / Nishiyama, A. / Yoshimi, S. / Yamaguchi, K. / Nagatoishi, S. / Ohta, M. / Tsumoto, K. / Nakanishi, M. / Defossez, P.A. / Ikeguchi, M. / Arita, K. |
External links | Bioorg. Med. Chem. / PubMed:34801826 |
| Methods | X-ray diffraction |
| Resolution | 1.45 Å |
| Structure data | ![]() PDB-7fb7: |
| Chemicals | ![]() ChemComp-MPD: ![]() ChemComp-8NF: ![]() ChemComp-DMS: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
| Source |
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Keywords | DNA BINDING PROTEIN / DNA methylation / histone modification / inhibitor |
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homo sapiens (human)
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