+Search query
-Structure paper
Title | Discovery of Extremely Selective Fused Pyridine-Derived beta-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 64, Page 14165-14174, Year 2021 |
Publish date | Jun 9, 2021 (structure data deposition date) |
![]() | Ueno, T. / Matsuoka, E. / Asada, N. / Yamamoto, S. / Kanegawa, N. / Ito, M. / Ito, H. / Moechars, D. / Rombouts, F.J.R. / Gijsen, H.J.M. / Kusakabe, K.I. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.5 - 2.05 Å |
Structure data | ![]() PDB-7f1d: ![]() PDB-7f1g: |
Chemicals | ![]() ChemComp-IOD: ![]() ChemComp-0QQ: ![]() ChemComp-HOH: |
Source |
|
![]() | HYDROLASE / Beta-secretase 1 / Beta-secretase 2 |