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Structure paper

TitleStructure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 7154-7163, Year 2021
Publish dateMar 21, 2021 (structure data deposition date)
AuthorsNakamura, T. / Okabe, K. / Hirayama, S. / Chirifu, M. / Ikemizu, S. / Morioka, H. / Nakabeppu, Y. / Yamagata, Y.
External linksNucleic Acids Res. / PubMed:34142156
MethodsX-ray diffraction
Resolution1.97 - 2.7 Å
Structure data

PDB-7ef8:
Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form I)
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-7ef9:
Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form II)
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-7efa:
Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DNA repair / DNA BINDING PROTEIN-DNA complex / DNA BINDING PROTEIN / DNA replication

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