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TitleDiscovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Journal, issue, pagesEur. J. Med. Chem., Vol. 226, Page 113819-113819, Year 2021
Publish dateJul 23, 2020 (structure data deposition date)
AuthorsVan Manh, N. / Hoang, V.H. / Ngo, V.T.H. / Ann, J. / Jang, T.H. / Ha, J.H. / Song, J.Y. / Ha, H.J. / Kim, H. / Kim, Y.H. / Lee, J.
External linksEur. J. Med. Chem. / PubMed:34536669
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7cm0:
Crystal structure of a glutaminyl cyclase in complex with NHV-1009
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-G5R:
1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]urea

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / glutaminyl cyclases (QCs) / Alzheimer disease

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