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-Structure paper
Title | Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 38, Page 127858-127858, Year 2021 |
Publish date | May 12, 2020 (structure data deposition date) |
![]() | Yamamoto, H. / Sakai, N. / Ohte, S. / Sato, T. / Sekimata, K. / Matsumoto, T. / Nakamura, K. / Watanabe, H. / Mishima-Tsumagari, C. / Tanaka, A. ...Yamamoto, H. / Sakai, N. / Ohte, S. / Sato, T. / Sekimata, K. / Matsumoto, T. / Nakamura, K. / Watanabe, H. / Mishima-Tsumagari, C. / Tanaka, A. / Hashizume, Y. / Honma, T. / Katagiri, T. / Miyazono, K. / Tomoda, H. / Shirouzu, M. / Koyama, H. |
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Methods | X-ray diffraction |
Resolution | 1.802 Å |
Structure data | ![]() PDB-7c3g: |
Chemicals | ![]() ChemComp-FH0: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / kinase / inhibitor complex |