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Structure paper

TitleStructure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.
Journal, issue, pagesNat Commun, Vol. 11, Page 5287-5287, Year 2020
Publish dateMar 26, 2020 (structure data deposition date)
AuthorsYan, W. / Cheng, L. / Wang, W. / Wu, C. / Yang, X. / Du, X. / Ma, L. / Qi, S. / Wei, Y. / Lu, Z. ...Yan, W. / Cheng, L. / Wang, W. / Wu, C. / Yang, X. / Du, X. / Ma, L. / Qi, S. / Wei, Y. / Lu, Z. / Yang, S. / Shao, Z.
External linksNat Commun / PubMed:33082324
MethodsX-ray diffraction
Resolution2.79 Å
Structure data

PDB-7br3:
Crystal structure of the protein 1
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-1QW:
(2R)-2,3-dihydroxypropyl dodecanoate

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-FMT:
FORMIC ACID

ChemComp-F5O:
4-[[(1R)-2-[5-(2-fluoranyl-3-methoxy-phenyl)-3-[[2-fluoranyl-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-1-phenyl-ethyl]amino]butanoic acid

Source
  • homo sapiens (human)
  • pyrococcus abyssi (strain ge5 / orsay) (archaea)
KeywordsSIGNALING PROTEIN / GPCR / helix / transmembrane

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