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TitleVitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants.
Journal, issue, pagesInt J Mol Sci, Vol. 23, Year 2022
Publish dateJan 22, 2021 (structure data deposition date)
AuthorsBelorusova, A.Y. / Rovito, D. / Chebaro, Y. / Doms, S. / Verlinden, L. / Verstuyf, A. / Metzger, D. / Rochel, N. / Laverny, G.
External linksInt J Mol Sci / PubMed:35955580
MethodsX-ray diffraction
Resolution2.4 - 2.7 Å
Structure data

PDB-7bns:
VDR complex with BXL-62
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7bnu:
VDR complex with BXL-62
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-U5W:
1,25-Dihydroxy-16-ene-20-cyclopropyl-vitamin D3

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor / agonist

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