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-Structure paper
Title | Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. |
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Journal, issue, pages | J. Biol. Chem., Vol. 296, Page 100568-100568, Year 2021 |
Publish date | Dec 7, 2020 (structure data deposition date) |
![]() | Rehling, D. / Zhang, S.M. / Jemth, A.S. / Koolmeister, T. / Throup, A. / Wallner, O. / Scaletti, E. / Moriyama, T. / Nishii, R. / Davies, J. ...Rehling, D. / Zhang, S.M. / Jemth, A.S. / Koolmeister, T. / Throup, A. / Wallner, O. / Scaletti, E. / Moriyama, T. / Nishii, R. / Davies, J. / Desroses, M. / Rudd, S.G. / Scobie, M. / Homan, E. / Berglund, U.W. / Yang, J.J. / Helleday, T. / Stenmark, P. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.45 - 1.6 Å |
Structure data | ![]() PDB-7b63: ![]() PDB-7b64: ![]() PDB-7b65: ![]() PDB-7b66: ![]() PDB-7b67: |
Chemicals | ![]() ChemComp-SYW: ![]() ChemComp-MG: ![]() ChemComp-HOH: ![]() ChemComp-PO4: |
Source |
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![]() | HYDROLASE / Inhibitor / complex / Nucleoside Triphosphate Pyrophosphohydrolase |