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TitleBistable Photoswitch Allows in Vivo Control of Hematopoiesis.
Journal, issue, pagesAcs Cent. Sci., Vol. 8, Page 57-66, Year 2022
Publish dateNov 10, 2020 (structure data deposition date)
AuthorsAlbert, L. / Nagpal, J. / Steinchen, W. / Zhang, L. / Werel, L. / Djokovic, N. / Ruzic, D. / Hoffarth, M. / Xu, J. / Kaspareit, J. ...Albert, L. / Nagpal, J. / Steinchen, W. / Zhang, L. / Werel, L. / Djokovic, N. / Ruzic, D. / Hoffarth, M. / Xu, J. / Kaspareit, J. / Abendroth, F. / Royant, A. / Bange, G. / Nikolic, K. / Ryu, S. / Dou, Y. / Essen, L.O. / Vazquez, O.
External linksAcs Cent. Sci. / PubMed:35106373
MethodsX-ray diffraction
Resolution1.562 - 2.432 Å
Structure data

PDB-7axp:
Structural characterisation of WDR5:CS-VIP8 interaction in cis state 2
Method: X-RAY DIFFRACTION / Resolution: 2.432 Å

PDB-7axq:
Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K
Method: X-RAY DIFFRACTION / Resolution: 1.562 Å

PDB-7axs:
Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-7axu:
Structure of WDR5:CS-VIP8 cocrystal after illumination in situ
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-7axx:
Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / WDR5 / cyclic strained visible-light photoswitches / MLL1 complex disruption / inhibition of hematopoiesis

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