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-Structure paper
| Title | Development of a small molecule that corrects misfolding and increases secretion of Z alpha 1 -antitrypsin. |
|---|---|
| Journal, issue, pages | Embo Mol Med, Vol. 13, Page e13167-e13167, Year 2021 |
| Publish date | Sep 17, 2020 (structure data deposition date) |
 Authors | Lomas, D.A. / Irving, J.A. / Arico-Muendel, C. / Belyanskaya, S. / Brewster, A. / Brown, M. / Chung, C.W. / Dave, H. / Denis, A. / Dodic, N. ...Lomas, D.A. / Irving, J.A. / Arico-Muendel, C. / Belyanskaya, S. / Brewster, A. / Brown, M. / Chung, C.W. / Dave, H. / Denis, A. / Dodic, N. / Dossang, A. / Eddershaw, P. / Klimaszewska, D. / Haq, I. / Holmes, D.S. / Hutchinson, J.P. / Jagger, A.M. / Jakhria, T. / Jigorel, E. / Liddle, J. / Lind, K. / Marciniak, S.J. / Messer, J. / Neu, M. / Olszewski, A. / Ordonez, A. / Ronzoni, R. / Rowedder, J. / Rudiger, M. / Skinner, S. / Smith, K.J. / Terry, R. / Trottet, L. / Uings, I. / Wilson, S. / Zhu, Z. / Pearce, A.C. |
 External links | Embo Mol Med / PubMed:33512066 |
| Methods | X-ray diffraction |
| Resolution | 1.76 Å |
| Structure data |  PDB-7ael: |
| Chemicals |  ChemComp-R7Z:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
|
 Keywords | PROTEIN BINDING / SERPIN / SERINE PROTEASE INHIBITOR |
homo sapiens (human)