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-Structure paper
Title | Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation. |
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Journal, issue, pages | Chem Sci, Vol. 12, Page 2286-2293, Year 2021 |
Publish date | Apr 30, 2020 (structure data deposition date) |
![]() | Hegedus, Z. / Hobor, F. / Shoemark, D.K. / Celis, S. / Lian, L.Y. / Trinh, C.H. / Sessions, R.B. / Edwards, T.A. / Wilson, A.J. |
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Methods | X-ray diffraction |
Resolution | 1.57 - 2.12 Å |
Structure data | ![]() PDB-6ywz: ![]() PDB-6yx0: ![]() PDB-6yx1: ![]() PDB-6yx2: |
Chemicals | ![]() ChemComp-PEG: ![]() ChemComp-PWN: ![]() ChemComp-THR: ![]() ChemComp-ARG: ![]() ChemComp-LEU: ![]() ChemComp-HOH: ![]() ChemComp-PWQ: ![]() ChemComp-PWT: ![]() ChemComp-PWW: |
Source |
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![]() | PEPTIDE BINDING PROTEIN / protein-protein interactions PDZ domain / hybrid structures / fragment-based drug discovery / beta-sheets / acylhydrazone / protein protein interactions PDZ domain hybrid structures / protein protein interactions / PDZ domain / beta-sheets acylhydrazone / PDZ domain hybrid structures |