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-Structure paper
Title | Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state. |
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Journal, issue, pages | J. Biol. Chem., Vol. 297, Page 101188-101188, Year 2021 |
Publish date | Jul 10, 2020 (structure data deposition date) |
![]() | Fenton, B.A. / Tomberg, J. / Sciandra, C.A. / Nicholas, R.A. / Davies, C. / Zhou, P. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.15 Å |
Structure data | ![]() PDB-6xqv: ![]() PDB-6xqx: ![]() PDB-6xqy: ![]() PDB-6xqz: |
Chemicals | ![]() ChemComp-9F2: ![]() ChemComp-SO4: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-EDO: |
Source |
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![]() | HYDROLASE / PBP2 / beta-lactam / antibiotic target / ceftriaxone / TRANSFERASE |