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-Structure paper
Title | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. |
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Journal, issue, pages | Sci Adv, Vol. 6, Year 2020 |
Publish date | Jun 3, 2020 (structure data deposition date) |
![]() | Sacco, M.D. / Ma, C. / Lagarias, P. / Gao, A. / Townsend, J.A. / Meng, X. / Dube, P. / Zhang, X. / Hu, Y. / Kitamura, N. ...Sacco, M.D. / Ma, C. / Lagarias, P. / Gao, A. / Townsend, J.A. / Meng, X. / Dube, P. / Zhang, X. / Hu, Y. / Kitamura, N. / Hurst, B. / Tarbet, B. / Marty, M.T. / Kolocouris, A. / Xiang, Y. / Chen, Y. / Wang, J. |
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Methods | X-ray diffraction |
Resolution | 1.45 - 1.7 Å |
Structure data | ![]() PDB-6xa4: ![]() PDB-6xbg: ![]() PDB-6xbh: ![]() PDB-6xbi: ![]() PDB-6xfn: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-NA: ![]() ChemComp-DMS: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / COVID / COVID19 / COVID-19 / SARS / SARS COV2 / COV / NCOV 19 / CORONAVIRUS / MAIN PROTEASE / 3CL / MPRO / PRO / VIRAL PROTEIN / GC376 / calpain inhibitor II / leupeptin / calpain / aldehyde / GC-376 / 3cl-like / a-ketoamide / alpheketoamide / alpha / ketoamide / PEPTIDOMIMETIC / PROTEASE / CYSTEINE / HYDROLASE-HYDROLASE INHIBITOR complex / UAW41 / UAW246 / UAW247 / UAW248 / 246 / 247 / 248 / HYDROLASE / calpain inhibitor XII / 12 / calpain inhibitor 12 |