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-Structure paper
Title | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. |
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Journal, issue, pages | Commun Biol, Vol. 4, Page 1048-1048, Year 2021 |
Publish date | Apr 9, 2020 (structure data deposition date) |
Authors | Shan, L. / Dyk, N.V. / Haskins, N. / Cook, K.M. / Rosenthal, K.L. / Mazor, R. / Dragulin-Otto, S. / Jiang, Y. / Wu, H. / Dall'Acqua, W.F. ...Shan, L. / Dyk, N.V. / Haskins, N. / Cook, K.M. / Rosenthal, K.L. / Mazor, R. / Dragulin-Otto, S. / Jiang, Y. / Wu, H. / Dall'Acqua, W.F. / Borrok, M.J. / Damschroder, M.M. / Oganesyan, V. |
External links | Commun Biol / PubMed:34497355 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.55 Å |
Structure data | PDB-6wib: PDB-6wmh: PDB-6wna: PDB-6wol: |
Chemicals | ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / antibody constant region / fragment crystallizable / mutated / neonatal receptor interaction / half-life / neonatal Fc receptor |