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-Structure paper
| Title | The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem., Vol. 28, Page 115791-115791, Year 2020 |
| Publish date | Mar 12, 2020 (structure data deposition date) |
 Authors | Cadilla, R. / Deaton, D.N. / Do, Y. / Elkins, P.A. / Ennulat, D. / Guss, J.H. / Holt, J. / Jeune, M.R. / King, A.G. / Klapwijk, J.C. ...Cadilla, R. / Deaton, D.N. / Do, Y. / Elkins, P.A. / Ennulat, D. / Guss, J.H. / Holt, J. / Jeune, M.R. / King, A.G. / Klapwijk, J.C. / Kramer, H.F. / Kramer, N.J. / Laffan, S.B. / Masuria, P.I. / McDougal, A.V. / Mortenson, P.N. / Musetti, C. / Peckham, G.E. / Pietrak, B.L. / Poole, C. / Price, D.J. / Rendina, A.R. / Sati, G. / Saxty, G. / Shearer, B.G. / Shewchuk, L.M. / Sneddon, H.F. / Stewart, E.L. / Stuart, J.D. / Thomas, D.N. / Thomson, S.A. / Ward, P. / Wilson, J.W. / Xu, T. / Youngman, M.A. |
 External links | Bioorg. Med. Chem. / PubMed:33059303 |
| Methods | X-ray diffraction |
| Resolution | 1.97 - 2.395 Å |
| Structure data |  PDB-6w58:  PDB-6w8h: |
| Chemicals |  ChemComp-GSH:  ChemComp-SWS:  ChemComp-HOH:  ChemComp-EDO:  ChemComp-TJG: |
| Source |
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 Keywords | HYDROLASE / Glutathione S-transferase / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)