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TitleTargeting a neoantigen derived from a common TP53 mutation.
Journal, issue, pagesScience, Vol. 371, Year 2021
Publish dateMar 12, 2020 (structure data deposition date)
AuthorsHsiue, E.H. / Wright, K.M. / Douglass, J. / Hwang, M.S. / Mog, B.J. / Pearlman, A.H. / Paul, S. / DiNapoli, S.R. / Konig, M.F. / Wang, Q. ...Hsiue, E.H. / Wright, K.M. / Douglass, J. / Hwang, M.S. / Mog, B.J. / Pearlman, A.H. / Paul, S. / DiNapoli, S.R. / Konig, M.F. / Wang, Q. / Schaefer, A. / Miller, M.S. / Skora, A.D. / Azurmendi, P.A. / Murphy, M.B. / Liu, Q. / Watson, E. / Li, Y. / Pardoll, D.M. / Bettegowda, C. / Papadopoulos, N. / Kinzler, K.W. / Vogelstein, B. / Gabelli, S.B. / Zhou, S.
External linksScience / PubMed:33649166
MethodsX-ray diffraction
Resolution3.53 Å
Structure data

PDB-6w51:
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
Method: X-RAY DIFFRACTION / Resolution: 3.53 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunotherapy / MHC-I / HLA-A2 / p53

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