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Structure paper

TitleDefining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.
Journal, issue, pagesBmc Biol., Vol. 18, Page 91-91, Year 2020
Publish dateMar 11, 2020 (structure data deposition date)
AuthorsTolbert, W.D. / Sherburn, R. / Gohain, N. / Ding, S. / Flinko, R. / Orlandi, C. / Ray, K. / Finzi, A. / Lewis, G.K. / Pazgier, M.
External linksBmc Biol. / PubMed:32693837
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-6w4m:
CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / ADCC AND NEUTRALIZING ANTI-HIV-1 ENV ANTIBODY N12-I2 / CD4I ANTIBODY / FAB FRAGMENT / HIV-1 GP120 / IMMUNE SYSTEM / CLADE A/E 93TH057 / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX

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