+Search query
-Structure paper
Title | Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 63, Page 4929-4956, Year 2020 |
Publish date | Feb 13, 2020 (structure data deposition date) |
Authors | Kokkonda, S. / Deng, X. / White, K.L. / El Mazouni, F. / White, J. / Shackleford, D.M. / Katneni, K. / Chiu, F.C.K. / Barker, H. / McLaren, J. ...Kokkonda, S. / Deng, X. / White, K.L. / El Mazouni, F. / White, J. / Shackleford, D.M. / Katneni, K. / Chiu, F.C.K. / Barker, H. / McLaren, J. / Crighton, E. / Chen, G. / Angulo-Barturen, I. / Jimenez-Diaz, M.B. / Ferrer, S. / Huertas-Valentin, L. / Martinez-Martinez, M.S. / Lafuente-Monasterio, M.J. / Chittimalla, R. / Shahi, S.P. / Wittlin, S. / Waterson, D. / Burrows, J.N. / Matthews, D. / Tomchick, D. / Rathod, P.K. / Palmer, M.J. / Charman, S.A. / Phillips, M.A. |
External links | J. Med. Chem. / PubMed:32248693 |
Methods | X-ray diffraction |
Resolution | 1.78 - 2.25 Å |
Structure data | PDB-6vtn: PDB-6vty: |
Chemicals | ChemComp-RL7: ChemComp-FMN: ChemComp-ORO: ChemComp-HOH: ChemComp-RLA: |
Source |
|
Keywords | OXIDOREDUCTASE / mitochondria / alpha-beta barrel |