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Structure paper

TitleStructure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers
Journal, issue, pagesCommun Chem, Vol. 3, Page 124-, Year 2020
Publish dateJan 23, 2020 (structure data deposition date)
AuthorsHuckaby, J.T. / Jacobs, T.M. / Li, Z. / Perna, R.J. / Wang, A. / Nicely, N.I. / Lai, S.K.
External linksCommun Chem / Search PubMed
MethodsX-ray diffraction
Resolution2.42 - 2.63 Å
Structure data

PDB-6vl8:
Anti-PEG antibody 6-3 Fab fragment in complex with PEG
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-6vl9:
Anti-PEG antibody 6-3 Fab fragment in complex with PEG
Method: X-RAY DIFFRACTION / Resolution: 2.63 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEU:
2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-9FO:
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / antibody / fab / PEG / anti-PEG / polymer / anti-drug

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