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Structure paper

TitleA single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.
Journal, issue, pagesNat Cancer, Year 2020
Publish dateDec 10, 2019 (structure data deposition date)
AuthorsShahine, A. / Rossjohn, J.
External linksNat Cancer / Search PubMed
MethodsX-ray diffraction
Resolution2.4 - 3.53 Å
Structure data

PDB-6v7y:
Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D5
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6v7z:
Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D22
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-6v80:
Crystal structure of human CD1d presenting alpha-Galactosylceramide in complex with NKT12 TCR and VHH nanobody 1D12
Method: X-RAY DIFFRACTION / Resolution: 3.53 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-AGH:
N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / Lipid / Nanobody

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