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Structure paper

TitleA V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite.
Journal, issue, pagesSci Adv, Vol. 6, Year 2020
Publish dateOct 30, 2019 (structure data deposition date)
AuthorsKumar, S. / Ju, B. / Shapero, B. / Lin, X. / Ren, L. / Zhang, L. / Li, D. / Zhou, Z. / Feng, Y. / Sou, C. ...Kumar, S. / Ju, B. / Shapero, B. / Lin, X. / Ren, L. / Zhang, L. / Li, D. / Zhou, Z. / Feng, Y. / Sou, C. / Mann, C.J. / Hao, Y. / Sarkar, A. / Hou, J. / Nunnally, C. / Hong, K. / Wang, S. / Ge, X. / Su, B. / Landais, E. / Sok, D. / Zwick, M.B. / He, L. / Zhu, J. / Wilson, I.A. / Shao, Y.
External linksSci Adv / PubMed:32938661
MethodsX-ray diffraction
Resolution2.06 - 2.7 Å
Structure data

PDB-6uuh:
Crystal structure of broad and potent HIV-1 neutralizing antibody 438-B11
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6uul:
Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-6uum:
Crystal structure of antibody 438-B11 DSS mutant (Cys98A-Cys100aA)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • streptococcus sp. 'group g' (bacteria)
KeywordsIMMUNE SYSTEM / V3 glycan supersite / human antibody / ANTI-HIV NEUTRALIZING ANTIBODY / VIRAL PROTEIN / anti-HIV1 neutralizing antibody

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