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-Structure paper
Title | Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 2489-2510, Year 2020 |
Publish date | Aug 29, 2019 (structure data deposition date) |
![]() | Kump, K.J. / Miao, L. / Mady, A.S.A. / Ansari, N.H. / Shrestha, U.K. / Yang, Y. / Pal, M. / Liao, C. / Perdih, A. / Abulwerdi, F.A. ...Kump, K.J. / Miao, L. / Mady, A.S.A. / Ansari, N.H. / Shrestha, U.K. / Yang, Y. / Pal, M. / Liao, C. / Perdih, A. / Abulwerdi, F.A. / Chinnaswamy, K. / Meagher, J.L. / Carlson, J.M. / Khanna, M. / Stuckey, J.A. / Nikolovska-Coleska, Z. |
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Methods | X-ray diffraction |
Resolution | 1.84 - 2.9 Å |
Structure data | ![]() PDB-6u63: ![]() PDB-6u64: ![]() PDB-6u65: ![]() PDB-6u67: ![]() PDB-6u6f: |
Chemicals | ![]() ChemComp-Q0D: ![]() ChemComp-HOH: ![]() ChemComp-Q0G: ![]() ChemComp-Q0A: ![]() ChemComp-EDO: ![]() ChemComp-ACT: ![]() ChemComp-PEG: ![]() ChemComp-Q01: ![]() ChemComp-BNL: ![]() ChemComp-PZY: |
Source |
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![]() | APOPTOSIS/INHIBITOR / anti-apoptotic / inhibitor / PROTEIN BINDING / APOPTOSIS-INHIBITOR complex / Apoptosis / Mcl1 / Bfl1/A1 / protein-protein interaction / BH3 mimetics / cancer |