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Structure paper

TitleMulticomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 59, Page 5235-5241, Year 2020
Publish dateOct 8, 2019 (structure data deposition date)
AuthorsRicardo, M.G. / Ali, A.M. / Plewka, J. / Surmiak, E. / Labuzek, B. / Neochoritis, C.G. / Atmaj, J. / Skalniak, L. / Zhang, R. / Holak, T.A. ...Ricardo, M.G. / Ali, A.M. / Plewka, J. / Surmiak, E. / Labuzek, B. / Neochoritis, C.G. / Atmaj, J. / Skalniak, L. / Zhang, R. / Holak, T.A. / Groves, M. / Rivera, D.G. / Domling, A.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:31944488
MethodsX-ray diffraction
Resolution1.8 - 2.4 Å
Structure data

PDB-6t2d:
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6t2e:
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6t2f:
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-M9E:
2-(methylamino)-~{N}-[[4-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide

ChemComp-HOH:
WATER

ChemComp-M9H:
2-(methylamino)-~{N}-[[3-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPEPTIDE BINDING PROTEIN / Inhibitor / Complex / MDM2 / Stapled peptides / Ugi MCR-based macrocyclizations

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