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Structure paper

TitleNek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Journal, issue, pagesBiochem. J., Vol. 477, Page 1525-1539, Year 2020
Publish dateJul 4, 2019 (structure data deposition date)
AuthorsByrne, M.J. / Nasir, N. / Basmadjian, C. / Bhatia, C. / Cunnison, R.F. / Carr, K.H. / Mas-Droux, C. / Yeoh, S. / Cano, C. / Bayliss, R.
External linksBiochem. J. / PubMed:32242624
MethodsX-ray diffraction
Resolution2 - 3.5 Å
Structure data

PDB-6s73:
Crystal structure of Nek7 SRS mutant bound to compound 51
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

PDB-6s75:
Crystal structure of Nek7 bound to compound 51
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-6s76:
Crystal structure of human Nek7
Method: X-RAY DIFFRACTION / Resolution: 3.38 Å

PDB-6sk9:
Nek2 bound to purine compound 51
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-F9N:
3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Kinase / mutant / inhibitor / TRANSFERASE / Ser/Thr protein kinase

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