EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
ジャーナル・号・ページ	Bioorg. Med. Chem., Vol. 28, Page 115196-115196, Year 2020
掲載日	2019年6月28日 (構造データの登録日)
著者	Kyriakis, E. / Karra, A.G. / Papaioannou, O. / Solovou, T. / Skamnaki, V.T. / Liggri, P.G.V. / Zographos, S.E. / Szennyes, E. / Bokor, E. / Kun, S. ...Kyriakis, E. / Karra, A.G. / Papaioannou, O. / Solovou, T. / Skamnaki, V.T. / Liggri, P.G.V. / Zographos, S.E. / Szennyes, E. / Bokor, E. / Kun, S. / Psarra, A.G. / Somsak, L. / Leonidas, D.D.
リンク	Bioorg. Med. Chem. / PubMed:31767404
手法	X線回折
解像度	2.3 - 2.45 Å
構造データ	PDB-6s4h: The crystal structure of glycogen phosphorylase in complex with 8 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-6s4k: The crystal structure of glycogen phosphorylase in complex with 12 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-6s4o: The crystal structure of glycogen phosphorylase in complex with 9 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-6s4p: The crystal structure of glycogen phosphorylase in complex with 13 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å PDB-6s4r: The crystal structure of glycogen phosphorylase in complex with 11 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6s51: The crystal structure of glycogen phosphorylase in complex with 10 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å PDB-6s52: The crystal structure of glycogen phosphorylase in complex with 14 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å
化合物	ChemComp-KUQ: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-phenyl-1~{H}-imidazol-4-yl)oxane-3,4,5-triol ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, 沈殿剤YM ChemComp-PLP: PYRIDOXAL-5'-PHOSPHATE ChemComp-HOH: WATER ChemComp-KVW: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(4-phenyl-1,3-thiazol-2-yl)oxane-3,4,5-triol ChemComp-KV5: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-naphthalen-2-yl-1~{H}-imidazol-4-yl)oxane-3,4,5-triol ChemComp-IMP: INOSINIC ACID ChemComp-KVE: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(4-naphthalen-2-yl-1,3-thiazol-2-yl)oxane-3,4,5-triol ChemComp-KVH: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-naphthalen-2-yl-1,3-thiazol-4-yl)oxane-3,4,5-triol ChemComp-KVQ: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-phenyl-1,3-thiazol-4-yl)oxane-3,4,5-triol ChemComp-KVN*: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(5-phenyl-1,2,3,4-tetrazol-2-yl)oxane-3,4,5-triol
由来	oryctolagus cuniculus (ウサギ)
キーワード	TRANSFERASE / phosphorylase / inhibitor / C-beta-D-glucopyranosyl imidazole / C-beta-D-glucopyranosyl thiazole / C-beta-D-glucopyranosyl tetrazole