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Title | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 19, Page 1018-1030, Year 2020 |
Publish date | Feb 25, 2019 (structure data deposition date) |
![]() | Hofmann, M.H. / Mani, R. / Engelhardt, H. / Impagnatiello, M.A. / Carotta, S. / Kerenyi, M. / Lorenzo-Herrero, S. / Bottcher, J. / Scharn, D. / Arnhof, H. ...Hofmann, M.H. / Mani, R. / Engelhardt, H. / Impagnatiello, M.A. / Carotta, S. / Kerenyi, M. / Lorenzo-Herrero, S. / Bottcher, J. / Scharn, D. / Arnhof, H. / Zoephel, A. / Schnitzer, R. / Gerstberger, T. / Sanderson, M.P. / Rajgolikar, G. / Goswami, S. / Vasu, S. / Ettmayer, P. / Gonzalez, S. / Pearson, M. / McConnell, D.B. / Kraut, N. / Muthusamy, N. / Moll, J. |
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Methods | X-ray diffraction |
Resolution | 2.19 - 2.7 Å |
Structure data | ![]() PDB-6qtg: ![]() PDB-6qtj: ![]() PDB-6r3s: |
Chemicals | ![]() ChemComp-JH8: ![]() ChemComp-HOH: ![]() ChemComp-JHK: ![]() ChemComp-JRE: ![]() ChemComp-EDO: ![]() ChemComp-FMT: |
Source |
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![]() | CELL CYCLE / Inhibitor / Complex / KINASE |