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Structure paper

TitlePolypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Journal, issue, pagesCell Chem Biol, Vol. 27, Page 657-667.e6, Year 2020
Publish dateJan 2, 2019 (structure data deposition date)
AuthorsKaplan, A. / Andrei, S.A. / van Regteren Altena, A. / Simas, T. / Banerjee, S.L. / Kato, N. / Bisson, N. / Higuchi, Y. / Ottmann, C. / Fournier, A.E.
External linksCell Chem Biol / PubMed:32220335
MethodsX-ray diffraction
Resolution1.615 - 1.72 Å
Structure data

PDB-6qdr:
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.615 Å

PDB-6qds:
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC
Method: X-RAY DIFFRACTION / Resolution: 1.72 Å

PDB-6qdt:
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.702 Å

PDB-6qdu:
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC
Method: X-RAY DIFFRACTION / Resolution: 1.632 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-HY5:
FC-NCPC

ChemComp-TPO:
PHOSPHOTHREONINE

Source
  • homo sapiens (human)
KeywordsCHAPERONE / Neuron Regeneration / PPI / phosphorylation

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