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Structure paper

TitlePharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.
Journal, issue, pagesTo Be Published
Publish dateAug 5, 2019 (structure data deposition date)
AuthorsSantana, A.G. / Robinson, K. / Vickers, C. / Chen, H. / Zhou, S. / Boraston, A.B. / Clarke, L.A. / Withers, S.G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.526 - 2.796 Å
Structure data

PDB-6q1n:
Glucocerebrosidase in complex with pharmacological chaperone IMX8
Method: X-RAY DIFFRACTION / Resolution: 2.526 Å

PDB-6q1p:
Glucocerebrosidase in complex with pharmacological chaperone norIMX8
Method: X-RAY DIFFRACTION / Resolution: 2.796 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-P9V:
(2R,3S,4S,5R)-2-[2-(methylsulfanyl)ethyl]piperidine-3,4,5-triol

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-P8Y:
(2S,3S,4S,5R)-2-{[(4-methylpentyl)sulfonyl]methyl}piperidine-3,4,5-triol

Source
  • homo sapiens (human)
KeywordsHYDROLASE/INHIBITOR / pharmacological chaperone / Gaucher disease / glycosidase / inhibitor / pKa / HYDROLASE / HYDROLASE-INHIBITOR complex

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