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| Title | Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 117, Page 4109-4116, Year 2020 |
| Publish date | Jun 25, 2019 (structure data deposition date) |
Authors | Cho, J. / Lee, M. / Cochrane, C.S. / Webster, C.G. / Fenton, B.A. / Zhao, J. / Hong, J. / Zhou, P. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:32041866 |
| Methods | X-ray diffraction |
| Resolution | 1.92 - 2.26 Å |
| Structure data | ![]() PDB-6ph9: ![]() PDB-6pib: ![]() PDB-6pj3: |
| Chemicals | ![]() ChemComp-MN: ![]() ChemComp-LP5: ![]() ChemComp-PG4: ![]() ChemComp-CA: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-OKV: ![]() ChemComp-OKY: |
| Source |
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Keywords | BIOSYNTHETIC PROTEIN / lipid A / LpxH / lipid X / AZ1 / inhibitor / JH-LPH-33 |
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klebsiella pneumoniae (bacteria)
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