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TitleStructure of formylpeptide receptor 2-G complex reveals insights into ligand recognition and signaling.
Journal, issue, pagesNat Commun, Vol. 11, Issue 1, Page 885, Year 2020
Publish dateFeb 14, 2020
AuthorsYouwen Zhuang / Heng Liu / X Edward Zhou / Ravi Kumar Verma / Parker W de Waal / Wonjo Jang / Ting-Hai Xu / Lei Wang / Xing Meng / Gongpu Zhao / Yanyong Kang / Karsten Melcher / Hao Fan / Nevin A Lambert / H Eric Xu / Cheng Zhang /
PubMed AbstractFormylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, ...Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligands with a large chemical diversity generated at different stages of inflammation to either promote or resolve inflammation in order to maintain a balanced inflammatory response. The mechanism underlying promiscuous ligand recognition and activation of FPRs is not clear. Here we report a cryo-EM structure of FPR2-G signaling complex with a peptide agonist. The structure reveals a widely open extracellular region with an amphiphilic environment for ligand binding. Together with computational docking and simulation, the structure suggests a molecular basis for the recognition of formylpeptides and a potential mechanism of receptor activation, and reveals conserved and divergent features in G coupling. Our results provide a basis for understanding the molecular mechanism of the functional promiscuity of FPRs.
External linksNat Commun / PubMed:32060286 / PubMed Central
MethodsEM (single particle)
Resolution3.17 Å
Structure data

20126

6omm

EMDB-20126, PDB-6omm:
Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi
Method: EM (single particle) / Resolution: 3.17 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-PLM:
PALMITIC ACID

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN / Formyl peptide receptor 2/lipoxin A4 receptor / GPCR / Gi protein

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