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TitleStereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Journal, issue, pagesEur. J. Med. Chem., Vol. 212, Page 113099-113099, Year 2021
Publish dateMar 26, 2019 (structure data deposition date)
AuthorsMaolanon, A. / Papangelis, A. / Kawiecki, D. / Mou, T.C. / Syrenne, J.T. / Yi, F. / Hansen, K.B. / Clausen, R.P.
External linksEur. J. Med. Chem. / PubMed:33383257
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-6odl:
Crystal structure of GluN2A agonist binding domain with 4-butyl-(S)-CCG-IV
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-M7V:
(1S,2R)-2-[(S)-amino(carboxy)methyl]-1-butylcyclopropane-1-carboxylic acid

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSPORT PROTEIN / NMDA RECEPTOR / ANTAGONIST / RECEPTOR

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