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-Structure paper
Title | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. |
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Journal, issue, pages | Nat Commun, Vol. 10, Page 2385-2385, Year 2019 |
Publish date | Feb 16, 2019 (structure data deposition date) |
![]() | Birkinshaw, R.W. / Gong, J.N. / Luo, C.S. / Lio, D. / White, C.A. / Anderson, M.A. / Blombery, P. / Lessene, G. / Majewski, I.J. / Thijssen, R. ...Birkinshaw, R.W. / Gong, J.N. / Luo, C.S. / Lio, D. / White, C.A. / Anderson, M.A. / Blombery, P. / Lessene, G. / Majewski, I.J. / Thijssen, R. / Roberts, A.W. / Huang, D.C.S. / Colman, P.M. / Czabotar, P.E. |
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Methods | X-ray diffraction |
Resolution | 1.62 - 2.2 Å |
Structure data | ![]() PDB-6o0k: ![]() PDB-6o0l: ![]() PDB-6o0m: ![]() PDB-6o0o: ![]() PDB-6o0p: |
Chemicals | ![]() ChemComp-LBM: ![]() ChemComp-2PE: ![]() ChemComp-HOH: ![]() ChemComp-PEG: ![]() ChemComp-CL: ![]() ChemComp-F3Q: |
Source |
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![]() | APOPTOSIS / BCL-2 / Venetoclax / complex / Protein-protein interface inhibitor / FDA approved drug complex / resistance mutation / S55746 |