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TitleDevelopment of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.
Journal, issue, pagesMabs, Vol. 11, Page 1175-1190, Year 2019
Publish dateJan 16, 2019 (structure data deposition date)
AuthorsBenschop, R.J. / Chow, C.K. / Tian, Y. / Nelson, J. / Barmettler, B. / Atwell, S. / Clawson, D. / Chai, Q. / Jones, B. / Fitchett, J. ...Benschop, R.J. / Chow, C.K. / Tian, Y. / Nelson, J. / Barmettler, B. / Atwell, S. / Clawson, D. / Chai, Q. / Jones, B. / Fitchett, J. / Torgerson, S. / Ji, Y. / Bina, H. / Hu, N. / Ghanem, M. / Manetta, J. / Wroblewski, V.J. / Lu, J. / Allan, B.W.
External linksMabs / PubMed:31181988
MethodsX-ray diffraction
Resolution1.914 - 2.14 Å
Structure data

PDB-6nou:
An scFv derived from ixekizumab
Method: X-RAY DIFFRACTION / Resolution: 1.914 Å

PDB-6nov:
A Fab derived from ixekizumab
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-12P:
DODECAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IL17 / IL-17 / Ixekizumab / scFv / antibody / Fab

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