EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
ジャーナル・号・ページ	Biochemistry, Vol. 59, Page 955-963, Year 2020
掲載日	2019年1月7日 (構造データの登録日)
著者	Batra, V.K. / Alnajjar, K.S. / Sweasy, J.B. / McKenna, C.E. / Goodman, M.F. / Wilson, S.H.
リンク	Biochemistry / PubMed:31999437
手法	X線回折
解像度	1.85 - 2.6 Å
構造データ	PDB-6nkr: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with dGTP 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-6nks: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP 手法: X-RAY DIFFRACTION / 解像度: 2.349 Å PDB-6nkt: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma difluoro analogue of dGTP 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6nku: Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with dGTP 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6nkv: Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6nkw: Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma-methylene dGTP 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-6nkx: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with dGTP 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-6nky: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 手法: X-RAY DIFFRACTION / 解像度: 2.094 Å PDB-6nkz: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma methylene dGTP 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-6nl0: Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CF2 analogue of dGTP 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-CL: Unknown entry / クロリド ChemComp-DGT: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE / dGTP ChemComp-HOH: WATER ChemComp-GFH: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE / 2′-デオキシ-5′-グアニル酸ヒドロキシ[(R)-フルオロ(ホスホノ)メチル]ホスフィノイル ChemComp-GFF: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE / dGTP analogueYM ChemComp-GGH*: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE
由来	homo sapiens (ヒト)
キーワード	transcription/dna / DNA Polymerase Beta / Conformational Change / enzyme mechanism / K289M / LFER / TRANSCRIPTION / transcription-dna complex