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| Title | Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist. |
|---|---|
| Journal, issue, pages | Nat. Chem. Biol., Vol. 14, Page 1059-1066, Year 2018 |
| Publish date | Oct 31, 2018 (structure data deposition date) |
Authors | Masureel, M. / Zou, Y. / Picard, L.P. / van der Westhuizen, E. / Mahoney, J.P. / Rodrigues, J.P.G.L.M. / Mildorf, T.J. / Dror, R.O. / Shaw, D.E. / Bouvier, M. ...Masureel, M. / Zou, Y. / Picard, L.P. / van der Westhuizen, E. / Mahoney, J.P. / Rodrigues, J.P.G.L.M. / Mildorf, T.J. / Dror, R.O. / Shaw, D.E. / Bouvier, M. / Pardon, E. / Steyaert, J. / Sunahara, R.K. / Weis, W.I. / Zhang, C. / Kobilka, B.K. |
External links | Nat. Chem. Biol. / PubMed:30327561 |
| Methods | X-ray diffraction |
| Resolution | 2.95934213525 Å |
| Structure data | ![]() PDB-6mxt: |
| Chemicals | ![]() ChemComp-K5Y: ![]() ChemComp-MG: ![]() ChemComp-NI: ![]() ChemComp-OLC: ![]() ChemComp-HTO: ![]() ChemComp-OLA: ![]() ChemComp-P33: ![]() ChemComp-HOH: |
| Source |
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Keywords | SIGNALING PROTEIN/HORMONE / G protein-coupled receptor / adrenergic receptor / asthma drug / active conformation / nanobody / SIGNALING PROTEIN-HORMONE complex / membrane protein |
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