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Structure paper

TitleFenestrations control resting-state block of a voltage-gated sodium channel.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 13111-13116, Year 2018
Publish dateOct 28, 2018 (structure data deposition date)
AuthorsGamal El-Din, T.M. / Lenaeus, M.J. / Zheng, N. / Catterall, W.A.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:30518562
MethodsX-ray diffraction
Resolution2.9 - 3.455 Å
Structure data

PDB-6mvv:
NavAb voltage-gated sodium channel, I217C/F203A
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6mvw:
NavAb voltage-gated sodium channel, I217C/F203W
Method: X-RAY DIFFRACTION / Resolution: 3.198 Å

PDB-6mvx:
NavAb Voltage-gated Sodium Channel, I217C, in Complex with Class 1C Anti-arrhythmic Flecainide
Method: X-RAY DIFFRACTION / Resolution: 3.455 Å

PDB-6mvy:
NavAb voltage-gated sodium channel, residues 1-226, crystallized in the presence of Class 1B Anti-arrhythmic drug Lidocaine
Method: X-RAY DIFFRACTION / Resolution: 3.002 Å

Chemicals

ChemComp-PX4:
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / DMPC, phospholipid*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-K4D:
Flecainide / medication*YM

ChemComp-SO4:
SULFATE ION

Source
  • arcobacter butzleri (strain rm4018) (bacteria)
KeywordsMEMBRANE PROTEIN / Ion channel Voltage-gated Sodium Channel

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