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TitleBoosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.
Journal, issue, pagesJ. Virol., Vol. 94, Year 2020
Publish dateSep 11, 2018 (structure data deposition date)
AuthorsEasterhoff, D. / Pollara, J. / Luo, K. / Tolbert, W.D. / Young, B. / Mielke, D. / Jha, S. / O'Connell, R.J. / Vasan, S. / Kim, J. ...Easterhoff, D. / Pollara, J. / Luo, K. / Tolbert, W.D. / Young, B. / Mielke, D. / Jha, S. / O'Connell, R.J. / Vasan, S. / Kim, J. / Michael, N.L. / Excler, J.L. / Robb, M.L. / Rerks-Ngarm, S. / Kaewkungwal, J. / Pitisuttithum, P. / Nitayaphan, S. / Sinangil, F. / Tartaglia, J. / Phogat, S. / Kepler, T.B. / Alam, S.M. / Wiehe, K. / Saunders, K.O. / Montefiori, D.C. / Tomaras, G.D. / Moody, M.A. / Pazgier, M. / Haynes, B.F. / Ferrari, G.
External linksJ. Virol. / PubMed:31776278
MethodsX-ray diffraction
Resolution2.62 - 3 Å
Structure data

PDB-6mfj:
Crystal structure of the ADCC potent antibody DH677.3 Fab elicited in the RV305 vaccine trial.
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

PDB-6mfp:
Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / ANTI-HIV-1 ENV ANTIBODY DH677.3 / CD4I ANTIBODY / ADCC / HIV-1 ENV / RV305 VACCINE TRIAL / VIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 GP120 / CLADE A/E 93TH057 / VIRAL PROTEIN-IMMUNE SYSTEM complex

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