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-Structure paper
Title | XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity. |
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Journal, issue, pages | Nature, Vol. 569, Page 289-292, Year 2019 |
Publish date | Sep 5, 2018 (structure data deposition date) |
Authors | Johansson, L.C. / Stauch, B. / McCorvy, J.D. / Han, G.W. / Patel, N. / Huang, X.P. / Batyuk, A. / Gati, C. / Slocum, S.T. / Li, C. ...Johansson, L.C. / Stauch, B. / McCorvy, J.D. / Han, G.W. / Patel, N. / Huang, X.P. / Batyuk, A. / Gati, C. / Slocum, S.T. / Li, C. / Grandner, J.M. / Hao, S. / Olsen, R.H.J. / Tribo, A.R. / Zaare, S. / Zhu, L. / Zatsepin, N.A. / Weierstall, U. / Yous, S. / Stevens, R.C. / Liu, W. / Roth, B.L. / Katritch, V. / Cherezov, V. |
External links | Nature / PubMed:31019305 |
Methods | X-ray diffraction |
Resolution | 2.8 - 3.3 Å |
Structure data | PDB-6me6: PDB-6me7: PDB-6me8: PDB-6me9: |
Chemicals | ChemComp-JEY: ChemComp-ZN: ChemComp-OLC: ChemComp-JEV: |
Source |
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Keywords | MEMBRANE PROTEIN / GPCR / melatonin receptor type 1B (MT2) / 2-phenylmelatonin / XFEL / LCP / BRIL / Rubredoxin / circadian rhythm / jetlag / type 2 diabetes / H208A mutation / N86D mutation / ramelteon |