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-Structure paper
Title | Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 26, Page 5934-5943, Year 2018 |
Publish date | Jul 2, 2018 (structure data deposition date) |
Authors | Zheng, X. / Jiang, Z. / Li, X. / Zhang, C. / Li, Z. / Wu, Y. / Wang, X. / Luo, H.B. / Xu, J. / Wu, D. |
External links | Bioorg. Med. Chem. / PubMed:30429100 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.37 Å |
Structure data | PDB-6a7a: PDB-6a7b: PDB-6ijx: |
Chemicals | ChemComp-NAP: ChemComp-9S0: ChemComp-HOH: ChemComp-DMF: ChemComp-JMS: |
Source |
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Keywords | OXIDOREDUCTASE / Aldo-keto reductase family 1 member C1 / 20-alpha-hydroxysteroid Dehydrogenase / alpha-HSD / Aldo-keto reductase family 1 member C3 / type 5 17-beta-hydroxysteroid dehydrogenase / prostaglandin F synthase / Inhibitor / Complex |